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Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence.
J Urol. 1996 Jan; 155(1):105-9; discussion 109-10.JU

Abstract

PURPOSE

We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence.

MATERIALS AND METHODS

A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.).

RESULTS

The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity.

CONCLUSIONS

Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies.

Authors+Show Affiliations

Department of Urology, University of Munich, Germany.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

7490803

Citation

Kriegmair, M, et al. "Detection of Early Bladder Cancer By 5-aminolevulinic Acid Induced Porphyrin Fluorescence." The Journal of Urology, vol. 155, no. 1, 1996, pp. 105-9; discussion 109-10.
Kriegmair M, Baumgartner R, Knüchel R, et al. Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. J Urol. 1996;155(1):105-9; discussion 109-10.
Kriegmair, M., Baumgartner, R., Knüchel, R., Stepp, H., Hofstädter, F., & Hofstetter, A. (1996). Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. The Journal of Urology, 155(1), 105-9; discussion 109-10.
Kriegmair M, et al. Detection of Early Bladder Cancer By 5-aminolevulinic Acid Induced Porphyrin Fluorescence. J Urol. 1996;155(1):105-9; discussion 109-10. PubMed PMID: 7490803.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Detection of early bladder cancer by 5-aminolevulinic acid induced porphyrin fluorescence. AU - Kriegmair,M, AU - Baumgartner,R, AU - Knüchel,R, AU - Stepp,H, AU - Hofstädter,F, AU - Hofstetter,A, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 105-9; discussion 109-10 JF - The Journal of urology JO - J Urol VL - 155 IS - 1 N2 - PURPOSE: We determined whether the sensitivity of detecting dysplasia or early bladder cancer can be improved by 5-aminolevulinic acid induced porphyrin fluorescence. MATERIALS AND METHODS: A 3% 5-aminolevulinic acid solution was instilled intravesically before cystoscopy in 104 patients. The 5-aminolevulinic acid induced porphyrin fluorescence was excited by violet light from a krypton ion laser (wavelength 406.7 nm.). RESULTS: The sensitivity of the fluorescence cystoscopy (96.9%) was significantly (p < 0.0001) greater than that of white light cystoscopy (72.7%). There was no impact on specificity. CONCLUSIONS: Due to the high sensitivity of the procedure fluorescence guided biopsies are recommended instead of random biopsies. SN - 0022-5347 UR - https://safeaccess.unboundmedicine.com/medline/citation/7490803/Detection_of_early_bladder_cancer_by_5_aminolevulinic_acid_induced_porphyrin_fluorescence_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-5347(01)66559-5 DB - PRIME DP - Unbound Medicine ER -